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Lisa's avatar

In over two years I have not come across one peptide that has any component to it that makes it have it for me so no peptides are not addictive. The peptides themselves are not addictive now if you have an addictive personality and you are a compulsive shopper and that respect it could be literally anything and once again it becomes a mental health issue. When you're labeled drug seeking you're labeled that because whether the person realizes it or not they're displaying signs of addiction. No not everyone who takes pain medication legitimately is addicted to it some people have legitimate chronic pain and have a need for it but unfortunately in this country addiction is at such an epidemic level it's very hard to tell the difference which is why most emergency rooms will not give you anything more than basic painkillers and they refer you back to your own physician. If you're telling me peptides can be addictive the peptides themselves are like opioids for instance and the peptides themselves can cause you to become addicted to them I would like for you to cite your proof on that because I'm going to argue that there is no peptide that is made up of a component that can cause that dependency in your body and I would compare it once again to a personality disorder such as compulsive shopping whereas it's not the peptide itself that has you addicted it's the compulsion to buy it which again has nothing to do with the substance

Peptide Reporter's avatar

As far as I know, peptides aren't dopaminergic in the same way opioids are. (Although little clinical evidence exists on how GLP-1s act on the brain, so it may in fact be the case that they produce a dopaminergic or serotonergic response in patients recovering from addiction or traumatic brain injury; again, this is not yet known definitively.) I'm talking, like you are, about habits and patterns and compulsions that produce a "reward response" in the addicted brain, and these do include everything from shopping to starving oneself and noticing the number has dropped on the scale to compulsively seeking sex and relationships. To be clear, the reward response *does* involve dopamine and serotonin production in the brain, so we can try to draw a bright line and say "this dopamine agonist is very different from that one because this one is direct whereas that one is indirect," but we are still more or less talking about the same thing.

Lisa's avatar

So now you completely changed your opinion because in the previous comment you flat out said peptides are addictive and when I challenge that this reply says I'm thinking along the same lines you are as behavior patterns I would say straddling the fence gets a little tricky you may want to pick a side of it to stand on. Also, GLP research for other than weight loss is plentiful. Results of trial completions have been announced quite often in just the past year alone. As a matter of fact there's been quite a bit of research done on all the major current GOP medications on addiction recovery and it's very very positive I'm starting to wonder how much about this subject you actually know. GLP meds I've been shown in research to alter the brains motivation and reward Pathways which contribute to helping a great deal in an addict staying in recovery. There is actually a large scale study done involving over 600,000 veterans showing the reduced risk of addiction to alcohol, cocaine, opioids, nicotine, etc. There are many large and small studies that have been published on this subject. I'm not sure what you mean when you say there aren't any yet supporting how foe instance, glp meds affect the brain in addicts. Please educate yourself better because a lot of us in the research peptide community have.

Peptide Reporter's avatar

I hear that you're frustrated with my responses! Our editorial staff is always looking for new pitches from science journalists, clinicians, and laypeople with an interest in peptides and peptide science. Since this is a rapid growth area (commercially and epistemically), there's much to cover. If you would like to pitch us an essay about GLP-1s and behavioral health, we'd love to read it. We compensate all writers whose pitches are commissioned: https://peptidereporter.substack.com/p/want-to-write-for-peptide-partners

Hope you have a great day, friend! :)

Lisa's avatar

Rapidly growing, yes. There are 13 separate glp meds that just successfully completed phase three trials. However, the studies I cited have been out for quite some time. You seem to like to white wash, excuse, and redirect attention when what you say is proven to be in error. Looking back on a few of your posts & responses I now wonder if you use AI to generate them because as we all know, the scope of AI's current knowledge on a lot of things is severely flawed.

Lisa's avatar

Peptide seeking? This has to do with mental health issues more than anything else. The term peptide seeking mirrors drug seeking which is addiction behavior. Eventually she will find her way to the actual peptide grey market where nobody asks for anything but money. Address the mental health issues that is the true root wanting peptides is a symptom not the root cause

Peptide Reporter's avatar

Hi Lisa! I actually agree with you, and I'm wondering how you see this as being different for peptides versus other controlled substances like opioids, etc.? Because of course those substances "sought" by addicts in medical settings also have legitimate clinical applications -- just like peptides. So is the case you're making that peptides could not become habit-forming? If so, I'm sorry to say that they can, just like many other drugs, foods, rituals, behaviors. The essay above is actually about addressing the root cause of the "symptom" that is wanting peptides, and determining whether continuing with a peptide protocol would actually be helpful or harmful to the patient's wellbeing.